Nishani is a consultant ophthalmic surgeon based at the University Hospital Southampton NHS Foundation Trust, specialising in glaucoma and cataract surgery.  She is regarded as a leading expert in the UK and is the president of the UK and Eire glaucoma society. Nishani has published in numerous international ophthalmology journals and co-authored the BMJ Best practice of primary open angle glaucoma 2023. She is currently the principal investigator of a large multi-centre research project looking at real-world data into open angle glaucoma management.